Drug interactions
Ketamine + Zuranolone
Severity: Major
Ketamine and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress central nervous system function, so combined use can worsen sedation, dizziness and impairment of psychomotor performance. Zuranolone carries a warning about driving impairment that may be compounded.
What this interaction means in plain words
Ketamine and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketamine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; zuranolone is a GABA-A positive modulator and ketamine is an NMDA antagonist.
What to do
Avoid the combination where possible; if ketamine is required, reduce doses and monitor sedation and respiratory status. Counsel patients against driving or operating machinery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketamine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Ketamine with Zuranolone?
MediHelp rates the interaction as major. Ketamine and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress central nervous system function, so combined use can worsen sedation, dizziness and impairment of psychomotor performance. Zuranolone carries a warning about driving impairment that may be compounded.
How serious is the interaction between Ketamine and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if ketamine is required, reduce doses and monitor sedation and respiratory status. Counsel patients against driving or operating machinery.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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