Drug interactions
Ketoconazole + Mometasone inhaled
Severity: Moderate
Ketoconazole and Mometasone inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can increase systemic mometasone levels, leading to cortisol suppression and systemic corticosteroid effects such as Cushingoid features. Risk is greater with prolonged use or higher doses.
What this interaction means in plain words
Ketoconazole and Mometasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4, reducing the first-pass and systemic clearance of mometasone.
What to do
Monitor for signs of hypercortisolism and adrenal suppression during extended co-therapy, and consider an alternative corticosteroid such as beclomethasone if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketoconazole and Mometasone inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Mometasone inhaled?
MediHelp rates the interaction as moderate. Ketoconazole and Mometasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can increase systemic mometasone levels, leading to cortisol suppression and systemic corticosteroid effects such as Cushingoid features. Risk is greater with prolonged use or higher doses.
How serious is the interaction between Ketoconazole and Mometasone inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hypercortisolism and adrenal suppression during extended co-therapy, and consider an alternative corticosteroid such as beclomethasone if long-term use is needed.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
