Drug interactions
Ketoconazole + Mometasone intranasal
Severity: Minor
Ketoconazole and Mometasone intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may increase systemic mometasone exposure from the small amount absorbed after intranasal use. Clinically significant systemic corticosteroid effects are uncommon at standard doses.
What this interaction means in plain words
Ketoconazole and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ketoconazole inhibits CYP3A4 metabolism of mometasone.
What to do
No dose change is usually needed; monitor for systemic corticosteroid effects if therapy is prolonged or high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Mometasone intranasal?
MediHelp rates the interaction as minor. Ketoconazole and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may increase systemic mometasone exposure from the small amount absorbed after intranasal use. Clinically significant systemic corticosteroid effects are uncommon at standard doses.
How serious is the interaction between Ketoconazole and Mometasone intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for systemic corticosteroid effects if therapy is prolonged or high doses are used.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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