Drug interactions
Ketoconazole + Nitrendipine
Severity: Moderate
Ketoconazole and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can raise nitrendipine concentrations, increasing hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Ketoconazole and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4-mediated metabolism of nitrendipine.
What to do
Monitor blood pressure and edema, and lower the nitrendipine dose if hypotension or vasodilatory effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Nitrendipine?
MediHelp rates the interaction as moderate. Ketoconazole and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can raise nitrendipine concentrations, increasing hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Ketoconazole and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and lower the nitrendipine dose if hypotension or vasodilatory effects develop.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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