Drug interactions
Ketoconazole + Octreotide
Severity: Moderate
Ketoconazole and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and octreotide can cause bradycardia, which adds to arrhythmic risk. The clinical effect is generally modest but relevant in patients with other risk factors.
What this interaction means in plain words
Ketoconazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation and bradycardia.
What to do
Check a baseline ECG and potassium and magnesium, and monitor the ECG during co-therapy. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Ketoconazole with Octreotide?
MediHelp rates the interaction as moderate. Ketoconazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and octreotide can cause bradycardia, which adds to arrhythmic risk. The clinical effect is generally modest but relevant in patients with other risk factors.
How serious is the interaction between Ketoconazole and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and potassium and magnesium, and monitor the ECG during co-therapy. Avoid adding further QT-prolonging drugs.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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