Drug interactions
ketoconazole + pimozide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked QT prolongation/arrhythmia risk.
Mechanism of action
CYP3A4 inhibition + additive QT.
Clinical management
Contraindicated; avoid.
Drug reference
References
Frequently asked questions
Can I take ketoconazole with pimozide?
The interaction is rated: Contraindicated. Marked QT prolongation/arrhythmia risk.
How serious is the interaction between ketoconazole and pimozide?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between ketoconazole and pimozide managed?
Contraindicated; avoid.
Why do ketoconazole and pimozide interact?
CYP3A4 inhibition + additive QT.
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