Drug interactions
Ketoconazole + Progesterone micronized
Severity: Moderate
Ketoconazole and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone undergoes extensive CYP3A4 metabolism in the gut and liver, so ketoconazole can increase its exposure. This may enhance sedation, dizziness and other progestogenic effects.
What this interaction means in plain words
Ketoconazole and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits intestinal and hepatic CYP3A4, reducing progesterone clearance.
What to do
Monitor for excessive drowsiness, dizziness and bleeding changes, and consider reducing the progesterone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Progesterone micronized?
MediHelp rates the interaction as moderate. Ketoconazole and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral micronized progesterone undergoes extensive CYP3A4 metabolism in the gut and liver, so ketoconazole can increase its exposure. This may enhance sedation, dizziness and other progestogenic effects.
How serious is the interaction between Ketoconazole and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and bleeding changes, and consider reducing the progesterone dose if adverse effects appear.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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