Drug interactions
Ketoconazole + Progesterone natural
Severity: Moderate
Ketoconazole and Progesterone natural: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Natural progesterone is cleared mainly by CYP3A4, so a strong inhibitor such as ketoconazole can increase its levels. Effects such as sedation, dizziness and bleeding irregularities may become more pronounced, especially with oral dosing.
What this interaction means in plain words
Ketoconazole and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4-mediated progesterone metabolism.
What to do
Monitor for progestogenic adverse effects such as sedation and bleeding changes, and lower the progesterone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Progesterone natural?
MediHelp rates the interaction as moderate. Ketoconazole and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Natural progesterone is cleared mainly by CYP3A4, so a strong inhibitor such as ketoconazole can increase its levels. Effects such as sedation, dizziness and bleeding irregularities may become more pronounced, especially with oral dosing.
How serious is the interaction between Ketoconazole and Progesterone natural?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as sedation and bleeding changes, and lower the progesterone dose if they occur.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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