Drug interactions
Ketoconazole + Quinupristin / dalfopristin
Severity: Minor
Ketoconazole and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, and ketoconazole is mainly a CYP3A4 inhibitor rather than a sensitive substrate. A clinically meaningful rise in ketoconazole exposure is not well documented and is unlikely to matter at usual doses.
What this interaction means in plain words
Ketoconazole and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, which could modestly reduce ketoconazole metabolism.
What to do
No routine action is needed; watch for ketoconazole adverse effects such as nausea or liver enzyme elevation during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Ketoconazole and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4, and ketoconazole is mainly a CYP3A4 inhibitor rather than a sensitive substrate. A clinically meaningful rise in ketoconazole exposure is not well documented and is unlikely to matter at usual doses.
How serious is the interaction between Ketoconazole and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; watch for ketoconazole adverse effects such as nausea or liver enzyme elevation during therapy.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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