Drug interactions
Ketoconazole + Tropisetron
Severity: Moderate
Ketoconazole and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can prolong the QT interval and may also modestly raise tropisetron levels. Together they could increase the risk of QT-related arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Ketoconazole and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition adding to tropisetron exposure.
What to do
Obtain an ECG and correct potassium and magnesium before use in at-risk patients. Consider an alternative antiemetic if there are other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Tropisetron?
MediHelp rates the interaction as moderate. Ketoconazole and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole can prolong the QT interval and may also modestly raise tropisetron levels. Together they could increase the risk of QT-related arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Ketoconazole and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium before use in at-risk patients. Consider an alternative antiemetic if there are other QT-prolonging drugs.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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