Drug interactions
Ketoconazole + Valoctocogene roxaparvovec
Severity: Moderate
Ketoconazole and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can raise liver enzymes. Combining a hepatotoxic drug with this gene therapy may increase liver injury and could blunt gene therapy benefit.
What this interaction means in plain words
Ketoconazole and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxicity; ketoconazole is hepatotoxic and the gene therapy commonly causes ALT elevation.
What to do
Monitor ALT and other liver tests regularly and consider alternative non-hepatotoxic antifungals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Ketoconazole with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Ketoconazole and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can raise liver enzymes. Combining a hepatotoxic drug with this gene therapy may increase liver injury and could blunt gene therapy benefit.
How serious is the interaction between Ketoconazole and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and other liver tests regularly and consider alternative non-hepatotoxic antifungals.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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