Drug interactions
Ketoconazole + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Ketoconazole and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases systemic exposure to both fluticasone furoate and vilanterol. This may cause systemic corticosteroid effects, including cortisol suppression, and beta-agonist cardiovascular effects.
What this interaction means in plain words
Ketoconazole and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for systemic corticosteroid effects, heart rate and potassium. Consider an alternative inhaled therapy if long-term coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Ketoconazole and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases systemic exposure to both fluticasone furoate and vilanterol. This may cause systemic corticosteroid effects, including cortisol suppression, and beta-agonist cardiovascular effects.
How serious is the interaction between Ketoconazole and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects, heart rate and potassium. Consider an alternative inhaled therapy if long-term coadministration is needed.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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