Drug interactions
Ketorolac + Streptomycin
Severity: Moderate
Ketorolac and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, especially in neonates, and both are nephrotoxic. This may raise streptomycin levels and the risk of kidney and vestibular or ototoxic injury.
What this interaction means in plain words
Ketorolac and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in renal prostaglandins and glomerular filtration decreases aminoglycoside clearance, with additive nephrotoxicity.
What to do
Monitor renal function and streptomycin levels and watch for hearing or balance changes. Avoid ketorolac in neonates and in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Streptomycin
Frequently asked questions
Can I take Ketorolac with Streptomycin?
MediHelp rates the interaction as moderate. Ketorolac and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, especially in neonates, and both are nephrotoxic. This may raise streptomycin levels and the risk of kidney and vestibular or ototoxic injury.
How serious is the interaction between Ketorolac and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels and watch for hearing or balance changes. Avoid ketorolac in neonates and in renal impairment.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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