Drug interactions
Ketorolac + Tenecteplase
Severity: Major
Ketorolac and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenecteplase is a fibrinolytic and ketorolac impairs platelet function and can injure the gastrointestinal mucosa. Together the risk of serious bleeding is increased.
What this interaction means in plain words
Ketorolac and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive effects of fibrinolysis and NSAID platelet inhibition on hemostasis.
What to do
Avoid ketorolac around thrombolysis and use a non-NSAID analgesic. Monitor for bleeding if both are given.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Ketorolac with Tenecteplase?
MediHelp rates the interaction as major. Ketorolac and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenecteplase is a fibrinolytic and ketorolac impairs platelet function and can injure the gastrointestinal mucosa. Together the risk of serious bleeding is increased.
How serious is the interaction between Ketorolac and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac around thrombolysis and use a non-NSAID analgesic. Monitor for bleeding if both are given.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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