Drug interactions
Ketorolac + Timolol
Severity: Moderate
Ketorolac and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the blood pressure lowering effect of beta-blockers, particularly with prolonged use. For ophthalmic timolol the systemic effect is smaller, but oral timolol may be affected.
What this interaction means in plain words
Ketorolac and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention, counteracting beta-blocker effects.
What to do
Monitor blood pressure when ketorolac is used with systemic timolol and keep the course short; adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Ketorolac with Timolol?
MediHelp rates the interaction as moderate. Ketorolac and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce the blood pressure lowering effect of beta-blockers, particularly with prolonged use. For ophthalmic timolol the systemic effect is smaller, but oral timolol may be affected.
How serious is the interaction between Ketorolac and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketorolac is used with systemic timolol and keep the course short; adjust antihypertensive therapy if control worsens.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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