Drug interactions
Ketorolac + Tolvaptan
Severity: Minor
Ketorolac and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no established clinically important interaction. Tolvaptan is a vasopressin antagonist that causes aquaresis and does not cause hyperkalemia, while ketorolac may reduce renal function in volume-depleted patients.
What this interaction means in plain words
Ketorolac and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketorolac belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
No well-established mechanism; theoretical additive renal effects if volume depletion occurs from tolvaptan-induced water loss.
What to do
Monitor renal function and serum sodium during tolvaptan therapy if ketorolac is required, and ensure adequate hydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ketorolac with Tolvaptan?
MediHelp rates the interaction as minor. Ketorolac and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no established clinically important interaction. Tolvaptan is a vasopressin antagonist that causes aquaresis and does not cause hyperkalemia, while ketorolac may reduce renal function in volume-depleted patients.
How serious is the interaction between Ketorolac and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum sodium during tolvaptan therapy if ketorolac is required, and ensure adequate hydration.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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