Drug interactions
Ketorolac + Triamterene
Severity: Major
Ketorolac and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ketorolac with triamterene increases the risk of hyperkalemia and acute kidney injury. Reported cases with NSAIDs and triamterene include reversible renal failure.
What this interaction means in plain words
Ketorolac and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
NSAID-induced prostaglandin inhibition lowers renal perfusion and potassium excretion, adding to the potassium-sparing effect of triamterene.
What to do
Avoid the combination where possible, especially in renal impairment or dehydration. If used, monitor serum potassium and creatinine and limit ketorolac duration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Ketorolac with Triamterene?
MediHelp rates the interaction as major. Ketorolac and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining ketorolac with triamterene increases the risk of hyperkalemia and acute kidney injury. Reported cases with NSAIDs and triamterene include reversible renal failure.
How serious is the interaction between Ketorolac and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in renal impairment or dehydration. If used, monitor serum potassium and creatinine and limit ketorolac duration.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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