Drug interactions
Ketorolac intranasal + Lisinopril
Severity: Major
Ketorolac intranasal and Lisinopril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically after intranasal use and as a potent NSAID can reduce the antihypertensive effect of lisinopril and impair renal function. The risk of acute kidney injury and hyperkalemia is higher with volume depletion, advanced age or renal disease.
What this interaction means in plain words
Ketorolac intranasal and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Avoid or limit the duration of ketorolac and use a non-NSAID analgesic where possible. If used, ensure hydration and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Ketorolac intranasal with Lisinopril?
MediHelp rates the interaction as major. Ketorolac intranasal and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is absorbed systemically after intranasal use and as a potent NSAID can reduce the antihypertensive effect of lisinopril and impair renal function. The risk of acute kidney injury and hyperkalemia is higher with volume depletion, advanced age or renal disease.
How serious is the interaction between Ketorolac intranasal and Lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit the duration of ketorolac and use a non-NSAID analgesic where possible. If used, ensure hydration and monitor blood pressure, creatinine and potassium.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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