Drug interactions
Ketorolac intranasal + Paroxetine
Severity: Major
Ketorolac intranasal and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs reduce platelet serotonin uptake and ketorolac inhibits platelet function and irritates the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding, even by the intranasal route since systemic exposure occurs.
What this interaction means in plain words
Ketorolac intranasal and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive impairment of platelet aggregation (serotonin depletion plus COX inhibition) and NSAID mucosal injury.
What to do
Avoid prolonged use and keep ketorolac to the shortest labeled course. Monitor for GI bleeding and consider an alternative analgesic in patients with bleeding risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketorolac intranasal and Paroxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Paroxetine?
MediHelp rates the interaction as major. Ketorolac intranasal and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. SSRIs reduce platelet serotonin uptake and ketorolac inhibits platelet function and irritates the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding, even by the intranasal route since systemic exposure occurs.
How serious is the interaction between Ketorolac intranasal and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged use and keep ketorolac to the shortest labeled course. Monitor for GI bleeding and consider an alternative analgesic in patients with bleeding risk factors.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
