Drug interactions
Ketorolac intranasal + Prednisolone
Severity: Moderate
Ketorolac intranasal and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs together increase the risk of gastrointestinal irritation, ulceration and bleeding. Intranasal ketorolac has lower systemic exposure than oral dosing but still carries NSAID class risk.
What this interaction means in plain words
Ketorolac intranasal and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit protective prostaglandins in the gastric mucosa while corticosteroids impair mucosal healing, giving additive GI injury.
What to do
Limit the duration of ketorolac use and counsel on GI bleeding symptoms. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Prednisolone?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs together increase the risk of gastrointestinal irritation, ulceration and bleeding. Intranasal ketorolac has lower systemic exposure than oral dosing but still carries NSAID class risk.
How serious is the interaction between Ketorolac intranasal and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of ketorolac use and counsel on GI bleeding symptoms. Consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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