Drug interactions
Ketorolac intranasal + Spironolactone
Severity: Moderate
Ketorolac intranasal and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is absorbed systemically and, like other NSAIDs, can impair renal function and potassium excretion. With spironolactone this raises the risk of hyperkalemia and acute kidney injury, and may blunt diuretic effect.
What this interaction means in plain words
Ketorolac intranasal and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and potassium excretion, adding to aldosterone antagonism.
What to do
Limit ketorolac to the shortest course and monitor serum potassium and creatinine; avoid in dehydration or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Ketorolac intranasal with Spironolactone?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is absorbed systemically and, like other NSAIDs, can impair renal function and potassium excretion. With spironolactone this raises the risk of hyperkalemia and acute kidney injury, and may blunt diuretic effect.
How serious is the interaction between Ketorolac intranasal and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course and monitor serum potassium and creatinine; avoid in dehydration or renal impairment.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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