Drug interactions
Ketorolac intranasal + Sulphasalazine
Severity: Moderate
Ketorolac intranasal and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is contraindicated in patients with significant bleeding risk and renal impairment, and NSAIDs can cause GI and renal toxicity. Sulfasalazine can cause blood dyscrasias and renal effects, so combined toxicity is plausible, but a specific interaction is poorly documented.
What this interaction means in plain words
Ketorolac intranasal and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping renal and hematologic toxicities; no specific interaction mechanism is established.
What to do
Limit ketorolac to short courses and monitor renal function and blood counts. Stop if bleeding or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Frequently asked questions
Can I take Ketorolac intranasal with Sulphasalazine?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is contraindicated in patients with significant bleeding risk and renal impairment, and NSAIDs can cause GI and renal toxicity. Sulfasalazine can cause blood dyscrasias and renal effects, so combined toxicity is plausible, but a specific interaction is poorly documented.
How serious is the interaction between Ketorolac intranasal and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to short courses and monitor renal function and blood counts. Stop if bleeding or renal decline occurs.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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