Drug interactions
Ketorolac intranasal + Tolvaptan
Severity: Minor
Ketorolac intranasal and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs like ketorolac can impair renal potassium excretion and raise serum potassium, and tolvaptan may also raise it. NSAIDs also may affect renal function, relevant in hyponatremia patients.
What this interaction means in plain words
Ketorolac intranasal and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-mediated reduction in renal prostaglandins and aldosterone may add to tolvaptan's potassium-raising effect.
What to do
Monitor serum potassium and renal function if used repeatedly or in renal impairment. Limit duration of ketorolac.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketorolac intranasal and Tolvaptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Tolvaptan?
MediHelp rates the interaction as minor. Ketorolac intranasal and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs like ketorolac can impair renal potassium excretion and raise serum potassium, and tolvaptan may also raise it. NSAIDs also may affect renal function, relevant in hyponatremia patients.
How serious is the interaction between Ketorolac intranasal and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if used repeatedly or in renal impairment. Limit duration of ketorolac.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
