Drug interactions
Ketorolac intranasal + Trandolapril
Severity: Major
Ketorolac intranasal and Trandolapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is systemically absorbed after intranasal use and is a potent NSAID. With an ACE inhibitor it can reduce antihypertensive efficacy and raise the risk of acute kidney injury and hyperkalemia, especially with dehydration or existing renal disease.
What this interaction means in plain words
Ketorolac intranasal and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion, compounded by ACE inhibitor loss of efferent arteriolar tone.
What to do
Avoid the combination where possible, and keep ketorolac courses very short if unavoidable. Monitor creatinine, potassium and blood pressure and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Ketorolac intranasal with Trandolapril?
MediHelp rates the interaction as major. Ketorolac intranasal and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is systemically absorbed after intranasal use and is a potent NSAID. With an ACE inhibitor it can reduce antihypertensive efficacy and raise the risk of acute kidney injury and hyperkalemia, especially with dehydration or existing renal disease.
How serious is the interaction between Ketorolac intranasal and Trandolapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and keep ketorolac courses very short if unavoidable. Monitor creatinine, potassium and blood pressure and ensure adequate hydration.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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