Drug interactions
Ketorolac intranasal + Triamterene
Severity: Moderate
Ketorolac intranasal and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an NSAID, and systemic absorption from the nasal route can still reduce renal prostaglandin synthesis. With triamterene this can cause hyperkalemia and acute kidney injury, and NSAIDs may also blunt diuretic effect.
What this interaction means in plain words
Ketorolac intranasal and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins reduces renin-aldosterone activity and renal perfusion, compounding triamterene's potassium retention.
What to do
Limit ketorolac to the shortest course and avoid in renal impairment or dehydration. Monitor serum potassium and creatinine during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Ketorolac intranasal with Triamterene?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is an NSAID, and systemic absorption from the nasal route can still reduce renal prostaglandin synthesis. With triamterene this can cause hyperkalemia and acute kidney injury, and NSAIDs may also blunt diuretic effect.
How serious is the interaction between Ketorolac intranasal and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketorolac to the shortest course and avoid in renal impairment or dehydration. Monitor serum potassium and creatinine during combined use.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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