Drug interactions
Ketorolac intranasal + Valsartan
Severity: Moderate
Ketorolac intranasal and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is a potent NSAID that can blunt the antihypertensive effect of valsartan and impair renal function, particularly in older or volume-depleted patients. Hyperkalemia risk is also increased. Systemic absorption from the nasal route is substantial, so the interaction is relevant.
What this interaction means in plain words
Ketorolac intranasal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces glomerular filtration and sodium excretion, adding to ARB-related efferent arteriolar dilation and potassium retention.
What to do
Keep ketorolac to the shortest duration and ensure adequate hydration. Monitor blood pressure, creatinine and potassium, and avoid in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Ketorolac intranasal with Valsartan?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is a potent NSAID that can blunt the antihypertensive effect of valsartan and impair renal function, particularly in older or volume-depleted patients. Hyperkalemia risk is also increased. Systemic absorption from the nasal route is substantial, so the interaction is relevant.
How serious is the interaction between Ketorolac intranasal and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest duration and ensure adequate hydration. Monitor blood pressure, creatinine and potassium, and avoid in patients with renal impairment or volume depletion.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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