Drug interactions
Ketotifen + Thiothixene
Severity: Moderate
Ketotifen and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic with sedative properties, and ketotifen is a sedating antihistamine. Combined use may increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Ketotifen and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from antipsychotic and H1-antihistamine activity.
What to do
Monitor for excessive sedation and counsel against driving until tolerance is known. Use a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Frequently asked questions
Can I take Ketotifen with Thiothixene?
MediHelp rates the interaction as moderate. Ketotifen and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic with sedative properties, and ketotifen is a sedating antihistamine. Combined use may increase drowsiness and impair alertness and coordination.
How serious is the interaction between Ketotifen and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel against driving until tolerance is known. Use a non-sedating antihistamine if needed.
What other medicines interact with Ketotifen?
MediHelp also lists interactions of Ketotifen with, for example, Phenobarbital, Pholcodine, Primidone. The full list is on the Ketotifen page.
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