Drug interactions
Ketotifen + Rotigotine
Severity: Moderate
Ketotifen and Rotigotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotigotine is a dopamine agonist that can cause somnolence and sudden sleep onset, and ketotifen is a sedating antihistamine. Together they may increase daytime drowsiness and the risk of falling asleep during activities.
What this interaction means in plain words
Ketotifen and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketotifen belongs to Respiratory; Rotigotine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects from dopaminergic somnolence and H1-antihistamine sedation.
What to do
Counsel patients about somnolence and avoiding driving if drowsy. Consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Sufentanil Moderate
Other interactions of Rotigotine
- Amisulpride + Rotigotine Major
- Metoclopramide + Rotigotine Major
- Amlodipine-benazepril + Rotigotine Moderate
- Benazepril + Rotigotine Moderate
- Captopril-hydrochlorothiazide + Rotigotine Moderate
- Captopril + Rotigotine Moderate
Frequently asked questions
Can I take Ketotifen with Rotigotine?
MediHelp rates the interaction as moderate. Ketotifen and Rotigotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotigotine is a dopamine agonist that can cause somnolence and sudden sleep onset, and ketotifen is a sedating antihistamine. Together they may increase daytime drowsiness and the risk of falling asleep during activities.
How serious is the interaction between Ketotifen and Rotigotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about somnolence and avoiding driving if drowsy. Consider a non-sedating antihistamine if needed.
What other medicines interact with Ketotifen?
MediHelp also lists interactions of Ketotifen with, for example, Phenobarbital, Pholcodine, Primidone. The full list is on the Ketotifen page.
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