Drug interactions
Ketotifen + Triazolam
Severity: Moderate
Ketotifen and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a short-acting benzodiazepine hypnotic, and ketotifen is a sedating antihistamine. Together they can increase sedation and psychomotor impairment, and older adults are at higher risk of confusion and falls.
What this interaction means in plain words
Ketotifen and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from GABA-A potentiation and H1-antihistamine activity.
What to do
Counsel on additive sedation and avoid driving after dosing. Prefer a non-sedating antihistamine and keep triazolam at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Frequently asked questions
Can I take Ketotifen with Triazolam?
MediHelp rates the interaction as moderate. Ketotifen and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a short-acting benzodiazepine hypnotic, and ketotifen is a sedating antihistamine. Together they can increase sedation and psychomotor impairment, and older adults are at higher risk of confusion and falls.
How serious is the interaction between Ketotifen and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive sedation and avoid driving after dosing. Prefer a non-sedating antihistamine and keep triazolam at the lowest effective dose.
What other medicines interact with Ketotifen?
MediHelp also lists interactions of Ketotifen with, for example, Phenobarbital, Pholcodine, Primidone. The full list is on the Ketotifen page.
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