Drug interactions
Ketotifen + Triclofos
Severity: Moderate
Ketotifen and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and ketotifen is a sedating antihistamine. Combined use may produce additive drowsiness and impaired alertness.
What this interaction means in plain words
Ketotifen and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from the sedative-hypnotic metabolite and H1-antihistamine activity.
What to do
Counsel on excess sedation and avoid driving after dosing. Choose a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Frequently asked questions
Can I take Ketotifen with Triclofos?
MediHelp rates the interaction as moderate. Ketotifen and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic that is converted to trichloroethanol, and ketotifen is a sedating antihistamine. Combined use may produce additive drowsiness and impaired alertness.
How serious is the interaction between Ketotifen and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on excess sedation and avoid driving after dosing. Choose a non-sedating antihistamine where possible.
What other medicines interact with Ketotifen?
MediHelp also lists interactions of Ketotifen with, for example, Phenobarbital, Pholcodine, Primidone. The full list is on the Ketotifen page.
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