Drug interactions
L-tryptophan + Rasagiline
Severity: Moderate
L-tryptophan and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
L-tryptophan is a serotonin precursor, and combining it with an MAO inhibitor may produce excess serotonin and serotonin syndrome. The risk is greatest with higher doses of either agent.
What this interaction means in plain words
L-tryptophan and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased serotonin synthesis plus reduced serotonin breakdown through MAO inhibition.
What to do
Avoid the combination where possible, or use the lowest doses. Monitor for agitation, tremor, clonus, hyperthermia and diarrhea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take L-tryptophan with Rasagiline?
MediHelp rates the interaction as moderate. L-tryptophan and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. L-tryptophan is a serotonin precursor, and combining it with an MAO inhibitor may produce excess serotonin and serotonin syndrome. The risk is greatest with higher doses of either agent.
How serious is the interaction between L-tryptophan and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses. Monitor for agitation, tremor, clonus, hyperthermia and diarrhea.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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