Drug interactions
Lamivudine + Valganciclovir
Severity: Moderate
Lamivudine and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can suppress bone marrow function, so use together may increase the risk of neutropenia, anemia and thrombocytopenia. The risk is greatest in patients with renal impairment or low baseline counts.
What this interaction means in plain words
Lamivudine and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamivudine belongs to Anti Virals; Valganciclovir belongs to Anti Virals.
Why it happens
Additive myelosuppressive pharmacodynamic effects.
What to do
Monitor complete blood counts regularly and interrupt or adjust therapy if marked cytopenias develop. Adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valganciclovir
Other interactions of Lamivudine
Frequently asked questions
Can I take Lamivudine with Valganciclovir?
MediHelp rates the interaction as moderate. Lamivudine and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can suppress bone marrow function, so use together may increase the risk of neutropenia, anemia and thrombocytopenia. The risk is greatest in patients with renal impairment or low baseline counts.
How serious is the interaction between Lamivudine and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and interrupt or adjust therapy if marked cytopenias develop. Adjust doses for renal function.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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