Drug interactions
Lamotrigine + Norgestrel
Severity: Moderate
Lamotrigine and Norgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norgestrel in combination with ethinylestradiol lowers lamotrigine concentrations, risking reduced seizure control. Progestin-only norgestrel is not expected to have a meaningful effect.
What this interaction means in plain words
Lamotrigine and Norgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Norgestrel belongs to Endocrine.
Why it happens
Estrogen-induced glucuronidation of lamotrigine.
What to do
For estrogen-containing products, monitor seizure control and adjust lamotrigine on starting or stopping. No adjustment is normally needed for progestin-only use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Lamotrigine with Norgestrel?
MediHelp rates the interaction as moderate. Lamotrigine and Norgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norgestrel in combination with ethinylestradiol lowers lamotrigine concentrations, risking reduced seizure control. Progestin-only norgestrel is not expected to have a meaningful effect.
How serious is the interaction between Lamotrigine and Norgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For estrogen-containing products, monitor seizure control and adjust lamotrigine on starting or stopping. No adjustment is normally needed for progestin-only use.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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