Drug interactions
Enzalutamide + Norgestrel
Severity: Major
Enzalutamide and Norgestrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower norgestrel concentrations, creating a risk of contraceptive failure and unintended pregnancy. The inducing effect persists for weeks after enzalutamide is stopped.
What this interaction means in plain words
Enzalutamide and Norgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Norgestrel belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, accelerating norgestrel metabolism.
What to do
Use an alternative or additional non-hormonal contraceptive method during treatment and for at least 28 days after stopping enzalutamide.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Norgestrel
Frequently asked questions
Can I take Enzalutamide with Norgestrel?
MediHelp rates the interaction as major. Enzalutamide and Norgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide may lower norgestrel concentrations, creating a risk of contraceptive failure and unintended pregnancy. The inducing effect persists for weeks after enzalutamide is stopped.
How serious is the interaction between Enzalutamide and Norgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative or additional non-hormonal contraceptive method during treatment and for at least 28 days after stopping enzalutamide.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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