Drug interactions
Lamotrigine + Orlistat
Severity: Moderate
Lamotrigine and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat has been linked to breakthrough seizures with antiseizure drugs, possibly through reduced absorption, though evidence for lamotrigine is limited to isolated reports.
What this interaction means in plain words
Lamotrigine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Orlistat belongs to Miscellaneous.
Why it happens
Orlistat-induced reduction in fat and drug absorption may lower lamotrigine levels; not firmly established.
What to do
Monitor seizure frequency and consider lamotrigine levels when orlistat is started or stopped; avoid orlistat if seizures are poorly controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Lamotrigine with Orlistat?
MediHelp rates the interaction as moderate. Lamotrigine and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat has been linked to breakthrough seizures with antiseizure drugs, possibly through reduced absorption, though evidence for lamotrigine is limited to isolated reports.
How serious is the interaction between Lamotrigine and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and consider lamotrigine levels when orlistat is started or stopped; avoid orlistat if seizures are poorly controlled.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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