Drug interactions
Lamotrigine + Paroxetine
Severity: Minor
Lamotrigine and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine has no major effect on lamotrigine exposure, and the combination is generally well tolerated. Additive drowsiness or dizziness may occur in some patients.
What this interaction means in plain words
Lamotrigine and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lamotrigine belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; possible additive CNS effects.
What to do
No dose change is routinely needed. Monitor for sedation and psychomotor impairment after starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Lamotrigine
Frequently asked questions
Can I take Lamotrigine with Paroxetine?
MediHelp rates the interaction as minor. Lamotrigine and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine has no major effect on lamotrigine exposure, and the combination is generally well tolerated. Additive drowsiness or dizziness may occur in some patients.
How serious is the interaction between Lamotrigine and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for sedation and psychomotor impairment after starting either drug.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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