Drug interactions
Lamotrigine + Zuranolone
Severity: Moderate
Lamotrigine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked somnolence and driving impairment, and lamotrigine adds CNS effects such as dizziness and drowsiness. Combined use may increase psychomotor impairment.
What this interaction means in plain words
Lamotrigine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lamotrigine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor for excessive sedation and consider reducing the zuranolone dose if it occurs. Advise against driving for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Lamotrigine with Zuranolone?
MediHelp rates the interaction as moderate. Lamotrigine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes marked somnolence and driving impairment, and lamotrigine adds CNS effects such as dizziness and drowsiness. Combined use may increase psychomotor impairment.
How serious is the interaction between Lamotrigine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the zuranolone dose if it occurs. Advise against driving for at least 12 hours after each dose.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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