Drug interactions
Lansoprazole + Lorlatinib
Severity: Minor
Lansoprazole and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower lansoprazole concentrations, potentially reducing acid suppression. The effect is likely modest because lansoprazole is also cleared by CYP2C19.
What this interaction means in plain words
Lansoprazole and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lansoprazole belongs to Gastrointestinal Tract; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolism of lansoprazole.
What to do
Monitor for reduced control of reflux or ulcer symptoms and increase the PPI dose if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lansoprazole with Lorlatinib?
MediHelp rates the interaction as minor. Lansoprazole and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A inducer and may lower lansoprazole concentrations, potentially reducing acid suppression. The effect is likely modest because lansoprazole is also cleared by CYP2C19.
How serious is the interaction between Lansoprazole and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced control of reflux or ulcer symptoms and increase the PPI dose if symptoms persist.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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