Drug interactions
Lansoprazole + Nilotinib
Severity: Major
Lansoprazole and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib capsules dissolve poorly at higher pH, so PPIs can reduce exposure and risk loss of leukemia control. Separating doses may not help due to long PPI action.
What this interaction means in plain words
Lansoprazole and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lansoprazole belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Higher gastric pH decreases nilotinib solubility and absorption.
What to do
Avoid PPIs and use a short-acting antacid or H2 blocker timed apart from nilotinib if needed. Monitor molecular response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Lansoprazole with Nilotinib?
MediHelp rates the interaction as major. Lansoprazole and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib capsules dissolve poorly at higher pH, so PPIs can reduce exposure and risk loss of leukemia control. Separating doses may not help due to long PPI action.
How serious is the interaction between Lansoprazole and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs and use a short-acting antacid or H2 blocker timed apart from nilotinib if needed. Monitor molecular response.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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