Drug interactions
Lansoprazole + Pazopanib
Severity: Major
Lansoprazole and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
PPIs can reduce pazopanib absorption because its solubility depends on gastric acidity, which may lower anticancer efficacy.
What this interaction means in plain words
Lansoprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lansoprazole belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Raised gastric pH reduces pazopanib solubility and absorption.
What to do
Avoid PPIs where possible. If acid suppression is essential, use a short-acting antacid separated from pazopanib by several hours.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Lansoprazole with Pazopanib?
MediHelp rates the interaction as major. Lansoprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. PPIs can reduce pazopanib absorption because its solubility depends on gastric acidity, which may lower anticancer efficacy.
How serious is the interaction between Lansoprazole and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs where possible. If acid suppression is essential, use a short-acting antacid separated from pazopanib by several hours.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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