Drug interactions
Albuterol + Lapatinib
Severity: Moderate
Albuterol and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and albuterol can also cause hypokalemia and tachycardia. Together they may increase the risk of arrhythmia, especially with systemic or high-dose albuterol.
What this interaction means in plain words
Albuterol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a contributing factor.
What to do
Check baseline ECG and electrolytes, and correct potassium and magnesium. Monitor the QTc during coadministration, particularly with high-dose or nebulized albuterol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Albuterol with Lapatinib?
MediHelp rates the interaction as moderate. Albuterol and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and albuterol can also cause hypokalemia and tachycardia. Together they may increase the risk of arrhythmia, especially with systemic or high-dose albuterol.
How serious is the interaction between Albuterol and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and correct potassium and magnesium. Monitor the QTc during coadministration, particularly with high-dose or nebulized albuterol.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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