Drug interactions
Larotrectinib + Pimozide
Severity: Moderate
Larotrectinib and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a modest CYP3A4 inhibitor and could raise pimozide levels. Because pimozide has a narrow therapeutic index and prolongs the QT interval, even a modest rise may matter.
What this interaction means in plain words
Larotrectinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Larotrectinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Larotrectinib inhibits CYP3A4, reducing pimozide metabolism.
What to do
Obtain a baseline ECG and monitor the QTc and electrolytes. Consider reducing the pimozide dose or choosing an alternative if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Pimozide?
MediHelp rates the interaction as moderate. Larotrectinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Larotrectinib is a modest CYP3A4 inhibitor and could raise pimozide levels. Because pimozide has a narrow therapeutic index and prolongs the QT interval, even a modest rise may matter.
How serious is the interaction between Larotrectinib and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc and electrolytes. Consider reducing the pimozide dose or choosing an alternative if the QTc lengthens.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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