Drug interactions
Larotrectinib + Theophylline
Severity: Minor
Larotrectinib and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro. Since theophylline is mainly cleared by CYP1A2, a clinically important rise in levels is unlikely.
What this interaction means in plain words
Larotrectinib and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by larotrectinib may slightly reduce a minor theophylline pathway.
What to do
Routine monitoring of theophylline levels or toxicity symptoms is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Theophylline?
MediHelp rates the interaction as minor. Larotrectinib and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro. Since theophylline is mainly cleared by CYP1A2, a clinically important rise in levels is unlikely.
How serious is the interaction between Larotrectinib and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine monitoring of theophylline levels or toxicity symptoms is sufficient.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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