Drug interactions
Larotrectinib + Ulipristal
Severity: Minor
Larotrectinib and Ulipristal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with possible weak inhibitory effect, so a small rise in ulipristal exposure is theoretically possible. Clinical relevance is unlikely with single-dose ulipristal.
What this interaction means in plain words
Larotrectinib and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition; not well established.
What to do
No specific adjustment is required; be aware of possible increased ulipristal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ulipristal?
MediHelp rates the interaction as minor. Larotrectinib and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with possible weak inhibitory effect, so a small rise in ulipristal exposure is theoretically possible. Clinical relevance is unlikely with single-dose ulipristal.
How serious is the interaction between Larotrectinib and Ulipristal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is required; be aware of possible increased ulipristal adverse effects.
What other medicines interact with Larotrectinib?
MediHelp also lists interactions of Larotrectinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Larotrectinib page.
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