Drug interactions
Larotrectinib + Venlafaxine
Severity: Minor
Larotrectinib and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, while CYP3A4 is a minor pathway for venlafaxine. A clinically significant increase in venlafaxine levels is unlikely.
What this interaction means in plain words
Larotrectinib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing venlafaxine metabolism.
What to do
No dose change is required routinely. Monitor for venlafaxine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Venlafaxine?
MediHelp rates the interaction as minor. Larotrectinib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, while CYP3A4 is a minor pathway for venlafaxine. A clinically significant increase in venlafaxine levels is unlikely.
How serious is the interaction between Larotrectinib and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required routinely. Monitor for venlafaxine adverse effects.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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