Drug interactions
Ledipasvir / sofosbuvir + Oxcarbazepine
Severity: Major
Ledipasvir / sofosbuvir and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
P-gp inducers can lower sofosbuvir and ledipasvir concentrations and compromise cure of hepatitis C.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Oxcarbazepine induces intestinal P-glycoprotein, reducing absorption of sofosbuvir and ledipasvir.
What to do
Avoid the combination; use an alternative anticonvulsant and monitor HCV response if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Oxcarbazepine?
MediHelp rates the interaction as major. Ledipasvir / sofosbuvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. P-gp inducers can lower sofosbuvir and ledipasvir concentrations and compromise cure of hepatitis C.
How serious is the interaction between Ledipasvir / sofosbuvir and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative anticonvulsant and monitor HCV response if unavoidable.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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