Drug interactions
Ledipasvir / sofosbuvir + Pantoprazole
Severity: Moderate
Ledipasvir / sofosbuvir and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir is less soluble at higher pH, so PPIs can reduce its absorption and could weaken the antiviral response. The effect is limited with low PPI doses taken together with the antiviral under fasted conditions.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH reduces the solubility and absorption of ledipasvir.
What to do
Give the PPI at a dose not exceeding that equivalent to omeprazole 20 mg, simultaneously with ledipasvir/sofosbuvir under fasting conditions. Avoid higher PPI doses during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Pantoprazole?
MediHelp rates the interaction as moderate. Ledipasvir / sofosbuvir and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir is less soluble at higher pH, so PPIs can reduce its absorption and could weaken the antiviral response. The effect is limited with low PPI doses taken together with the antiviral under fasted conditions.
How serious is the interaction between Ledipasvir / sofosbuvir and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the PPI at a dose not exceeding that equivalent to omeprazole 20 mg, simultaneously with ledipasvir/sofosbuvir under fasting conditions. Avoid higher PPI doses during treatment.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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