Drug interactions
Ledipasvir / sofosbuvir + Safinamide
Severity: Minor
Ledipasvir / sofosbuvir and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir and sofosbuvir are BCRP substrates, and safinamide may inhibit intestinal BCRP. Their exposure could rise modestly, with limited clinical significance expected.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP efflux may increase absorption of the antivirals.
What to do
No routine adjustment is needed; monitor for adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Safinamide?
MediHelp rates the interaction as minor. Ledipasvir / sofosbuvir and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ledipasvir and sofosbuvir are BCRP substrates, and safinamide may inhibit intestinal BCRP. Their exposure could rise modestly, with limited clinical significance expected.
How serious is the interaction between Ledipasvir / sofosbuvir and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for adverse effects such as headache and fatigue.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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