Drug interactions
Ledipasvir-sofosbuvir + Tenofovir df
Severity: Moderate
Ledipasvir-sofosbuvir and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir/sofosbuvir increases tenofovir exposure, which can raise the risk of kidney injury and bone mineral density loss. The risk is greater with other nephrotoxins or pre-existing renal impairment.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-gp and BCRP inhibition by ledipasvir increases intestinal absorption of tenofovir.
What to do
Monitor renal function, urinalysis and serum phosphate during therapy; consider an alternative such as tenofovir alafenamide in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ledipasvir-sofosbuvir and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Tenofovir df?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir/sofosbuvir increases tenofovir exposure, which can raise the risk of kidney injury and bone mineral density loss. The risk is greater with other nephrotoxins or pre-existing renal impairment.
How serious is the interaction between Ledipasvir-sofosbuvir and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, urinalysis and serum phosphate during therapy; consider an alternative such as tenofovir alafenamide in high-risk patients.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
