Drug interactions
Lefamulin + Metformin
Severity: Moderate
Lefamulin and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin may raise metformin exposure. Higher metformin levels could increase gastrointestinal effects and, in vulnerable patients, the risk of lactic acidosis.
What this interaction means in plain words
Lefamulin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Metformin belongs to Endocrine.
Why it happens
Lefamulin may inhibit renal organic cation transporters (OCT2/MATE) that eliminate metformin.
What to do
Monitor for metformin adverse effects and glycemic control, particularly in patients with renal impairment. Consider reducing the metformin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lefamulin and Metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Other interactions of Metformin
Frequently asked questions
Can I take Lefamulin with Metformin?
MediHelp rates the interaction as moderate. Lefamulin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin may raise metformin exposure. Higher metformin levels could increase gastrointestinal effects and, in vulnerable patients, the risk of lactic acidosis.
How serious is the interaction between Lefamulin and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects and glycemic control, particularly in patients with renal impairment. Consider reducing the metformin dose if needed.
What other medicines interact with Lefamulin?
MediHelp also lists interactions of Lefamulin with, for example, Methadone, Pimavanserin, Pimozide. The full list is on the Lefamulin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
